Email this article New synthesis of 4-methoxyisophthalic acid
- Authors: Liu X.J.1, Yan Y.N.1, Wang S.Q.2, Li X.1, Liu X.G.1
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Affiliations:
- School of Chemistry and Chemical Engineering
- School of Pharmaceutical Science and Technology
- Issue: Vol 53, No 3 (2017)
- Pages: 459-461
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/215996
- DOI: https://doi.org/10.1134/S1070428017030241
- ID: 215996
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Abstract
A new synthetic route to 4-methoxyisophthalic acid, the key intermediate in the synthesis of Picotamide, is reported. The new protocol starts from commercially available and cheap 4-methylphenol and includes four steps: esterification, Fries rearrangement, methylation, and oxidation; the overall yield is 49%. Unlike the traditional Blanc chloromethylation/oxidation scheme, the proposed procedure avoids using volatile and corrosive hydrochloric acid.
About the authors
X. J. Liu
School of Chemistry and Chemical Engineering
Author for correspondence.
Email: liuxiujie@hotmail.com
China, Tianjin, 300384
Y. N. Yan
School of Chemistry and Chemical Engineering
Email: xuguangliu@yahoo.com
China, Tianjin, 300384
S. Q. Wang
School of Pharmaceutical Science and Technology
Email: xuguangliu@yahoo.com
China, Tianjin, 300072
X. Li
School of Chemistry and Chemical Engineering
Email: xuguangliu@yahoo.com
China, Tianjin, 300384
X. G. Liu
School of Chemistry and Chemical Engineering
Author for correspondence.
Email: xuguangliu@yahoo.com
China, Tianjin, 300384
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