Email this article Synthesis and antimicrobial activity of tryptanthrin adducts with ketones
- Authors: Deryabin P.I.1, Moskovkina T.V.1, Shevchenko L.S.2, Kalinovskii A.I.2
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Affiliations:
- Far Eastern Federal University
- Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch
- Issue: Vol 53, No 3 (2017)
- Pages: 418-422
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/215946
- DOI: https://doi.org/10.1134/S1070428017030174
- ID: 215946
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Abstract
Reactions of tryptanthrin with acetone, cyclopentanone, hexan-2-one, 4-methylpentan-2-one, 4-hydroxy-4-methylpentan-2-one, cyclohexanone, and butan-2-one in the presence of potassium carbonate afforded racemic phaitanthrin A and other addition products to the ketone group of tryptanthrin with high yields. Thermal dissociation, some chemical transformations, and antimicrobial activity of some adducts were studied, and inhibitory effect against gram-positive bacteria was found for particular derivatives.
About the authors
P. I. Deryabin
Far Eastern Federal University
Email: moskovkinataisiya@mail.ru
Russian Federation, ul. Sukhanova 8, Vladivostok, 690091
T. V. Moskovkina
Far Eastern Federal University
Author for correspondence.
Email: moskovkinataisiya@mail.ru
Russian Federation, ul. Sukhanova 8, Vladivostok, 690091
L. S. Shevchenko
Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch
Email: moskovkinataisiya@mail.ru
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
A. I. Kalinovskii
Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch
Email: moskovkinataisiya@mail.ru
Russian Federation, pr. 100 let Vladivostoku 159, Vladivostok, 690022
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