Email this article Synthesis of substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols
- Authors: Os’kina I.A.1, Tikhonov A.Y.1
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Affiliations:
- Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
- Issue: Vol 53, No 2 (2017)
- Pages: 236-239
- Section: Article
- URL: https://journals.rcsi.science/1070-4280/article/view/215780
- DOI: https://doi.org/10.1134/S1070428017020166
- ID: 215780
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Abstract
Substituted 2-(thiophen-2-yl)-1H-imidazol-1-ols were synthesized by cyclization of the corresponding α-thienyl nitrones in alkaline medium. α-Thienyl nitrones were obtained by reaction of N-(1-hydroxyimine-1-R-propan-2-yl)hydroxylamines with thiophene-2-carbaldehyde in methanol. At boiling α-thienyl nitrones in methanol in the presence of sodium methylate 5-aryl(hetaryl)-2-(thiophen-2-yl)-1H-imidazol-1-ols are formed chemoselectively.
About the authors
I. A. Os’kina
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
Author for correspondence.
Email: oi@nioch.nsc.ru
Russian Federation, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090
A. Ya. Tikhonov
Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch
Email: oi@nioch.nsc.ru
Russian Federation, pr. Akademika Lavrent’eva 9, Novosibirsk, 630090
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