Synthesis of D,L-Lactide–ε-Caprolactone Copolymers and Preparation of Films Based on Them

Yu. A. Nashchekina; K. E. Kurdyukova; I. M. Zorin; D. M. Darvish; E. S. Tsobkallo; M. I. Blinova; A. Yu. Bilibin

doi:10.1134/S1070427218010184

Synthesis of D,L-Lactide–ε-Caprolactone Copolymers and Preparation of Films Based on Them

Authors: Nashchekina Y.A.¹^,2, Kurdyukova K.E.³, Zorin I.M.³, Darvish D.M.¹, Tsobkallo E.S.⁴, Blinova M.I.¹, Bilibin A.Y.³
Affiliations:
1. Institute of Cytology
2. Ioffe Institute
3. Institute of Chemistry
4. Peter the Great Polytechnic University
Issue: Vol 91, No 1 (2018)
Pages: 113-120
Section: Macromolecular Compounds and Polymeric Materials
URL: https://journals.rcsi.science/1070-4272/article/view/215587
DOI: https://doi.org/10.1134/S1070427218010184
ID: 215587

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Abstract

D,L-Lactide–ε-caprolactone copolymers were synthesized by polymerization in the bulk. Films of these copolymers were prepared, and their strain properties and degradation rate under physiological conditions were studied. Introduction of ε-caprolactone into the copolymer increases the film elasticity and decreases the degradation rate compared to poly(D,L-lactide) homopolymer, and also favors spreading of human keratinocytes. The films obtained can be used for treatment of wounds and burns.