Synthesis and Antimicrobial Activity of Norbornene-Containing Mannich Bases

Resumo

Representatives of a new generation of norbornene aminomethoxy derivatives were prepared by Mannich condensation of norbornenylmethanol, formaldehyde, and secondary amines. The structures of the compounds were confirmed by elemental analysis, mass spectrometry, and IR and ¹H, ¹³C NMR spectroscopy. The compounds were tested as antimicrobial and antifungal agents. They show higher antimicrobial performance than the presently used agents do. The minimum inhibitory and minimum bactericidal concentrations were determined.