Complex-Emulsion synthesis of organo-inorganic amphiphilic sorbents with specific affinity for glucose
- Авторы: Borovikova L.N.1, Kipper A.I.1, Pisarev O.A.1,2, Polyakova I.V.1
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Учреждения:
- Institute of Macromolecular Compounds
- Peter the Great State Polytechnic University
- Выпуск: Том 90, № 6 (2017)
- Страницы: 901-909
- Раздел: Special Technology Solutions
- URL: https://journals.rcsi.science/1070-4272/article/view/214967
- DOI: https://doi.org/10.1134/S1070427217060106
- ID: 214967
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Аннотация
Granular organo-inorganic amphiphilic sorbents with specific affinity for glucose were synthesized with the aim of developing selective hemosorbents for efferent therapy of hyperglycemia. The sorbents were prepared in oil/water/oil complex emulsions by copolymerization of 2-hydroxyethyl methacrylate and ethylene glycol dimethacrylate on the surface of selenium nanoparticles stabilized with polyvinylpyrrolidone. The phases were stabilized with excess selenium/polyvinylpyrrolidone nanocomplexes. Optimum synthesis conditions ensuring formation of hybrid sorbents with the physicochemical properties required for performing efficient preparative hemosorption and plasma adsorption processes were found. The specific affinity for glucose was reached by modification of these sorbents via imprinting with template glucose molecules in the surface polymer layer and via introduction of boric acid as an affine ligand into the hybrid matrices.
Об авторах
L. Borovikova
Institute of Macromolecular Compounds
Email: pol_irina_val@list.ru
Россия, Birzhevoi pr. 6, St. Petersburg, 199034
A. Kipper
Institute of Macromolecular Compounds
Email: pol_irina_val@list.ru
Россия, Birzhevoi pr. 6, St. Petersburg, 199034
O. Pisarev
Institute of Macromolecular Compounds; Peter the Great State Polytechnic University
Email: pol_irina_val@list.ru
Россия, Birzhevoi pr. 6, St. Petersburg, 199034; Politekhnicheskaya ul. 29, St. Petersburg, 195251
I. Polyakova
Institute of Macromolecular Compounds
Автор, ответственный за переписку.
Email: pol_irina_val@list.ru
Россия, Birzhevoi pr. 6, St. Petersburg, 199034
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