Copolymer of N,N-diallyl-N,N-dimethylammonium chloride with maleic acid as drug carrier
- Авторы: Vorob’eva A.I.1, Babaev M.S.1, Spirikhin L.V.1, Shishlov N.M.1, Kolesov S.V.1
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Учреждения:
- Ufa Institute of Chemistry
- Выпуск: Том 89, № 1 (2016)
- Страницы: 160-164
- Раздел: Macromolecular Compounds and Polymeric Materials
- URL: https://journals.rcsi.science/1070-4272/article/view/213514
- DOI: https://doi.org/10.1134/S1070427216010250
- ID: 213514
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Аннотация
A copolymer of N,N-diallyl-N,N-dimethylammonium chloride with maleic acid of constant composition was prepared under the conditions of radical initiation. The possibility of the functionalization of the copolymer with drugs containing amino groups by polymer-analogous transformations was examined. Conditions were found for preparing conjugates of the copolymer with isoniazid. The structures and the quantitative compositions of the conjugates were determined by 13С NMR spectroscopy, and the possibility of preparing conjugates with controlled drug content was demonstrated.
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Об авторах
A. Vorob’eva
Ufa Institute of Chemistry
Автор, ответственный за переписку.
Email: b.marat.c@mail.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
M. Babaev
Ufa Institute of Chemistry
Email: b.marat.c@mail.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
L. Spirikhin
Ufa Institute of Chemistry
Email: b.marat.c@mail.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
N. Shishlov
Ufa Institute of Chemistry
Email: b.marat.c@mail.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
S. Kolesov
Ufa Institute of Chemistry
Email: b.marat.c@mail.ru
Россия, pr. Oktyabrya 71, Ufa, Bashkortostan, 450054
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