A Water Soluble Zinc(II) Coordination Polymer Containing Pyridazine-4,5-Dicarboxylic Acid: The Crystal Structure and Binding Properties with DNA
- Authors: Liu Y.Q.1,2, Luo X.M.1, Jiang H.J.2, Zhang Z.Q.2
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Affiliations:
- School of Basic Medical Sciences
- School of Pharmacy
- Issue: Vol 44, No 5 (2018)
- Pages: 317-321
- Section: Article
- URL: https://journals.rcsi.science/1070-3284/article/view/214488
- DOI: https://doi.org/10.1134/S1070328418050032
- ID: 214488
Cite item
Abstract
New water soluble complex [Zn(HPDDA)2(H2O)2(4,4'-Bipy)2]n (I), where H2PDDA is pyridazine- 4,5-dicarboxylic acid, 4,4'-Bipy = 4,4'-bipyridine), has been prepared by hydrothermal reaction and structurally characterized by X-ray single-crystal diffraction analysis (CIF file CCDC no. 835525 ) and elemental analysis. In I, each Zn2+ ion is six-coordinated by two oxygen atoms from the two HPDDA ligands, two nitrogen atoms from two 4,4'-Bipy and two oxygen atoms from two water molecules. The interactions of I with calf thymus DNA were studied by circular dichroism spectroscopy. The results indicated that this water soluble zinc complex show moderate binding with DNA and could be used for candidate for therapy of cancer.
Keywords
About the authors
Y. Q. Liu
School of Basic Medical Sciences; School of Pharmacy
Email: zhangzhq@njmu.edu.cn
China, Nanjing, Jiangsu Province, 211166; Nanjing, Jiangsu Province, 211166
X. M. Luo
School of Basic Medical Sciences
Email: zhangzhq@njmu.edu.cn
China, Nanjing, Jiangsu Province, 211166
H. J. Jiang
School of Pharmacy
Email: zhangzhq@njmu.edu.cn
China, Nanjing, Jiangsu Province, 211166
Z. Q. Zhang
School of Pharmacy
Author for correspondence.
Email: zhangzhq@njmu.edu.cn
China, Nanjing, Jiangsu Province, 211166
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