Self-Consistent Description of Adsorption and Changes in the Adsorption Center Structure
- Authors: Arakelyan V.B.1, Harutyunyan S.V.2, Kocharyan S.P.2
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Affiliations:
- Yerevan State University
- Yerevan State Medical University Named After Mkhitar Heratsi
- Issue: Vol 54, No 4 (2019)
- Pages: 394-402
- Section: Article
- URL: https://journals.rcsi.science/1068-3372/article/view/229020
- DOI: https://doi.org/10.3103/s1068337219040108
- ID: 229020
Cite item
Abstract
The adsorption of ligands to macromolecules is theoretically investigated in this work in the case when the structure of the adsorption center changes when a ligand is bound to the macromolecule. In this case, the adsorption kinetics is described by a set of two nonlinear differential equations. This consideration results in such properties that the adsorption center acquires the multiplicity of stationary states (including the bistable states), trigger and hysteresis behavior. It is shown that taking into account the deformation of the adsorption center results in an S-shaped adsorption isotherm.
Keywords
About the authors
V. B. Arakelyan
Yerevan State University
Author for correspondence.
Email: v.arakelyan@ysu.am
Armenia, Yerevan
S. V. Harutyunyan
Yerevan State Medical University Named After Mkhitar Heratsi
Email: v.arakelyan@ysu.am
Armenia, Yerevan
S. P. Kocharyan
Yerevan State Medical University Named After Mkhitar Heratsi
Email: v.arakelyan@ysu.am
Armenia, Yerevan