Sensitivity of DNA Sensors in the Presence of Charged Ligands

Sh. A. Tonoyan; A. A. Hakobyan; A. K. Andreassian; V. F. Morozov; Y. Sh. Mamasakhlisov

doi:10.3103/S1068337218020111

Sensitivity of DNA Sensors in the Presence of Charged Ligands

Authors: Tonoyan S.A.¹, Hakobyan A.A.², Andreassian A.K.¹, Morozov V.F.¹, Mamasakhlisov Y.S.¹
Affiliations:
1. Yerevan State University
2. Institute of Radiophysics and Electronics
Issue: Vol 53, No 2 (2018)
Pages: 179-186
Section: Article
URL: https://journals.rcsi.science/1068-3372/article/view/228640
DOI: https://doi.org/10.3103/S1068337218020111
ID: 228640

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Abstract
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Abstract

Factors that influence both the thermodynamics of hybridization and the stability of the DNA–DNA duplexes are analyzed. The noncompetitive DNA hybridization cases in the presence of mono- and bivalent positively charged ligands have been investigated and the comparison is made with the case of uncharged ligands. It has been shown that the charged ligands enhance the sensitivity of the DNA chips as compared with the uncharged ones.