New synthesis of 3,3-disubstituted piperidin-2-ones from esters and 1-(3-halopropyl)-2,5-dimethylpyrroles
- 作者: Gvozdev V.1, Shavrin K.1, Nefedov O.1
-
隶属关系:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- 期: 卷 68, 编号 11 (2019)
- 页面: 2108-2113
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243535
- DOI: https://doi.org/10.1007/s11172-019-2674-1
- ID: 243535
如何引用文章
详细
3,3-Disubstituted piperidin-2-ones were obtained by alkylation of carboxylic acid esters with 1-(3-halopropyl)-2,5-dimethylpyrroles using lithium diisopropylamide as a base followed by the removal of 2,5-dimethylpyrrole protection and intramolecular cyclization. The overall yields of the target products amounted to 78% in two synthetic steps.
作者简介
V. Gvozdev
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: vgvozdev2006@yandex.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
K. Shavrin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vgvozdev2006@yandex.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
O. Nefedov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vgvozdev2006@yandex.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991