Utilization of potassium carbonate for the synthesis of 2-(organylsulfonyl)thieno[2,3-b]pyridine derivatives
- 作者: Kalugin V.1, Shestopalov A.1
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隶属关系:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- 期: 卷 68, 编号 2 (2019)
- 页面: 357-364
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243254
- DOI: https://doi.org/10.1007/s11172-019-2393-7
- ID: 243254
如何引用文章
详细
A novel preparative method for the synthesis of 2-(organylsulfonyl)thieno[2,3-b]pyridine derivatives has been developed, which allows one to obtain the desired products in a good yield and to shorten the reaction duration. The reaction of 3-cyanopyridine-2(1H)-thiones with chloromethyl organyl sulfones in the presence of potassium carbonate as the base gave 2-(organylsulfonyl) thieno[2,3-b]pyridine-3-amines. The same reaction of methyl 4,6-dimethylpyridine- 2(1H)-thione-3-carboxylate with chloromethyl organyl sulfones resulted in tautomeric mixtures of 4,6-dimethyl-2-(organylsulfonyl)thieno[2,3-b]pyridine-3-oles and 4,6-dimethyl-2-(organylsulfonyl) thieno[2,3-b]pyridine-3(2H)-ones.
作者简介
V. Kalugin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: vek@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991
A. Shestopalov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vek@ioc.ac.ru
俄罗斯联邦, 47 Leninsky prosp., Moscow, 119991