New chlorin-terpene conjugates bearing triethylene glycol and cationic tetraalkylammonium fragments
- 作者: Mal’shakova M.1, Frolova L.1, Alekseev I.1, Kutchin A.1, Patov S.1, Belykh D.1
-
隶属关系:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- 期: 卷 67, 编号 8 (2018)
- 页面: 1467-1475
- 栏目: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242833
- DOI: https://doi.org/10.1007/s11172-018-2241-1
- ID: 242833
如何引用文章
详细
Methyl pheophorbide a reacts with terpene alcohols on activation with the Mukaiyama reagent to give the products of the formal transesterification of the C(21)CO2Me group. To increase hydrophilicity, the synthesized conjugates were modified following two different paths. The first path is the acid-catalyzed transesterification of the C(3)(CH2)2CO2Me moiety of the conjugate with triethylene glycol to give diester with different substituents and different ester groups. The second path is the treatment of terpenyl ester with N,N-dimethylethylenediamine that proceeds via the phorbin exocycle opening to give the porphine derivatives bearing two ester and one carboxamide groups. The dimethylamino groups of these porphine derivatives were quaternized with iodomethane.
作者简介
M. Mal’shakova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
编辑信件的主要联系方式.
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982
L. Frolova
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982
I. Alekseev
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982
A. Kutchin
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982
S. Patov
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982
D. Belykh
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: dahlia-m@rambler.ru
俄罗斯联邦, 48 ul. Pervomaiskaya, Syktyvkar, 167982