Pro- and antioxidant characteristics of natural thiols
- 作者: Zinatullina K.1,2, Kasaikina O.1,3, Kuzmin V.2,3, Khrameeva N.2
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隶属关系:
- N. Semenov Institute of Chemical Physics, Russian Academy of Sciences
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Department of Chemistry, M. V. Lomonosov Moscow State University
- 期: 卷 67, 编号 4 (2018)
- 页面: 726-730
- 栏目: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242452
- DOI: https://doi.org/10.1007/s11172-018-2129-0
- ID: 242452
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详细
In aqueous solutions at physiological temperature, the mechanism of antioxidative action of natural thiols (glutathione, cysteine, and homocysteine) mainly involves reactions with reactive oxygen species (ROS), peroxyl radicals and hydrogen peroxide. Reduction of hydrogen peroxide by thiols is accompanied by radical generation. The kinetic characteristics of these processes, including those for the reactions of hydrogen peroxide and glutathione immobilized on solid supports such as sodium montmorillonite (clay) and cellulose were determined. Prooxidative effects of thiols are related with the reactions of thiyl radicals formed in the exchange reactions of thiols with other radicals and in the reactions between thiols and hydroperoxides. Thiyl radicals are known to react easily with double bonds. Resveratrol and caffeic acid, phenolic antioxidants containing double bond in their molecules, were shown to be consumed when reacted with glutathione and the process accelerated in the presence of hydrogen peroxide.
作者简介
K. Zinatullina
N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: Karinazinat11@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119991; 4 ul. Kosygina, Moscow, Russian Federation, 119991
O. Kasaikina
N. Semenov Institute of Chemical Physics, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: Karinazinat11@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119991; Build. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991
V. Kuzmin
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences; Department of Chemistry, M. V. Lomonosov Moscow State University
Email: Karinazinat11@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119991; Build. 3, 1 Leninskie Gory, Moscow, Russian Federation, 119991
N. Khrameeva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: Karinazinat11@gmail.com
俄罗斯联邦, 4 ul. Kosygina, Moscow, Russian Federation, 119991