Synthesis of nitrogen-containing derivatives of 17(20)-pregnenoic, 17β-hydroxypregnanoic, and 17α-hydroxypregnanoic acids as new potential antiandrogens
- 作者: Zolottsev V.1, Kostin V.1, Novikov R.2, Tkachev Y.2, Zavialova M.1, Taratynova M.1, Latysheva A.1, Zazulina O.1, Timofeev V.2, Misharin A.1
-
隶属关系:
- V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
- V. A. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
- 期: 卷 67, 编号 4 (2018)
- 页面: 667-681
- 栏目: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242431
- DOI: https://doi.org/10.1007/s11172-018-2121-8
- ID: 242431
如何引用文章
详细
A general scheme for the synthesis of oxazoline and benzoxazole derivatives of [17(20)E]-21-norpregnene differing in the structure of the steroid moiety as well as amides of 17β-hydroxy-3-oxopregn-4-en-21-oic and 17α-hydroxy-3-oxopregn-4-en-21-oic acids was developed. The scheme involved synthesis of the steroid building blocks (appropriately protected derivatives of pregn-17(20)-en-21-oic, 17β-hydroxypregnan-21-oic, and 17α-hydroxypregnan-21-oic acids) and subsequent transformation of these building blocks into the target compounds. Following the developed scheme, synthesis of new nitrogen-containing steroid derivatives exhibiting antiandrogenic activity was enabled.
作者简介
V. Zolottsev
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
编辑信件的主要联系方式.
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
V. Kostin
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
R. Novikov
V. A. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 32 ul. Vavilova, Moscow, Russian Federation, 119991
Ya. Tkachev
V. A. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 32 ul. Vavilova, Moscow, Russian Federation, 119991
M. Zavialova
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
M. Taratynova
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
A. Latysheva
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
O. Zazulina
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121
V. Timofeev
V. A. Engelhardt Institute of Molecular Biology of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 32 ul. Vavilova, Moscow, Russian Federation, 119991
A. Misharin
V. N. Orekhovich Institute of Biomedical Chemistry of Russian Academy of Sciences
Email: vazolottsev@mail.ru
俄罗斯联邦, 10, Build. 8 ul. Pogodinskaya, Moscow, Russian Federation, 119121