Polyfunctional branched nitrogen-containing p-tert-butylthiacalix[4]arene derivatives as efficient agents for packaging calf thymus DNA
- 作者: Yakimova L.1, Puplampu J.1, Evtugin G.1, Stoikov I.1
-
隶属关系:
- Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute
- 期: 卷 66, 编号 8 (2017)
- 页面: 1515-1523
- 栏目: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241157
- DOI: https://doi.org/10.1007/s11172-017-1917-2
- ID: 241157
如何引用文章
详细
Polyfunctional p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with nitrogen-containing fragments in the cone, partial cone, and 1,3-alternate conformations were investigated in the processes of calf thymus DNA packaging. The influence of the macrocycle structure and composition on their ability to pack DNA into nano-sized particles was considered. UV spectroscopy and dynamic light scattering results showed that the synthesized p-tert-butylthiacalix[4]arenes functionalized at the lower rim with polyamine fragments in the cone and 1,3-alternate conformations can compact calf thymus DNA into nanosized particles (<100 nm). A new type of synthetic receptors based on the 1,3-alternate stereoisomer of p-tert-butylthiacalix[4]arene with ester, hydroxy, and tertiary amino groups was suggested for packaging DNA to nanoparticles of 51—85 nm in size.
作者简介
L. Yakimova
Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute
Email: gevtugyn@mail.ru
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008
J. Puplampu
Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute
Email: gevtugyn@mail.ru
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008
G. Evtugin
Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute
编辑信件的主要联系方式.
Email: gevtugyn@mail.ru
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008
I. Stoikov
Kazan (Volga Region) Federal University, A. M. Butlerov Chemical Institute
Email: gevtugyn@mail.ru
俄罗斯联邦, 18 ul. Kremlevskaya, Kazan, 420008