Synthesis and pharmacological activity of a silicon—zinc—boron-containing glycerohydrogel
- Авторы: Khonina T.1,2, Chupakhin O.1,3, Kungurov N.4, Zilberberg N.4, Evstigneeva N.4, Kokhan M.4, Polishchuk A.4, Permikin V.1, Shadrina E.1, Nikitin E.1, Larionov L.5
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Учреждения:
- Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis
- Ural State Agrarian University
- Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Chemical Engineering
- Ural Research Institute for Dermatology, Venereology, and Immunopathology
- Ministry of Health of the Russian Federation, Ural State Medical University
- Выпуск: Том 68, № 8 (2019)
- Страницы: 1621-1628
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243462
- DOI: https://doi.org/10.1007/s11172-019-2601-5
- ID: 243462
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Аннотация
A new pharmacologically active nanostructured silicon—zinc—boron-containing glycerohydrogel was synthesized by the sol—gel method using silicon, zinc, and boron glycerolates as biocompatible precursors. The hydrogel composition and structural features were investigated by transmission electron microscopy, powder X-ray diffraction, IR spectroscopy, atomic emission spectrometry, and elemental analysis; a structural model was proposed. It was found that the 3D framework of the gel is formed by the products of hydrolysis and subsequent (co)condensation of silicon- and boron-containing precursors. Meanwhile, the major part of zinc monoglycerolate does not undergo hydrolytic transformations during gelation, being present in the 3D framework cells as amorphous nano-sized particles. The dispersion medium of the gel is an aqueous glycerol solution of silicon and boron glycerolates, products of their hydrolytic transformations, and water-soluble products of hydrolytic transformations of zinc monoglycerolate. The silicon—zinc—boron gel is nontoxic and possesses wound-healing and antimicrobial activities; it can be considered as a nanostructured dispersed system promising for biomedical applications, which is prepared in a simple and cost-effective way without using catalysts or toxic organic solvents.
Об авторах
T. Khonina
Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis; Ural State Agrarian University
Автор, ответственный за переписку.
Email: khonina@ios.uran.ru
Россия, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990; 42 ul. K. Libknekhta, Ekaterinburg, 620075
O. Chupakhin
Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis; Ural Federal University named after the first President of Russia B. N. Yeltsin, Institute of Chemical Engineering
Email: khonina@ios.uran.ru
Россия, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
N. Kungurov
Ural Research Institute for Dermatology, Venereology, and Immunopathology
Email: khonina@ios.uran.ru
Россия, 8 ul. Shcherbakova, Ekaterinburg, 620076
N. Zilberberg
Ural Research Institute for Dermatology, Venereology, and Immunopathology
Email: khonina@ios.uran.ru
Россия, 8 ul. Shcherbakova, Ekaterinburg, 620076
N. Evstigneeva
Ural Research Institute for Dermatology, Venereology, and Immunopathology
Email: khonina@ios.uran.ru
Россия, 8 ul. Shcherbakova, Ekaterinburg, 620076
M. Kokhan
Ural Research Institute for Dermatology, Venereology, and Immunopathology
Email: khonina@ios.uran.ru
Россия, 8 ul. Shcherbakova, Ekaterinburg, 620076
A. Polishchuk
Ural Research Institute for Dermatology, Venereology, and Immunopathology
Email: khonina@ios.uran.ru
Россия, 8 ul. Shcherbakova, Ekaterinburg, 620076
V. Permikin
Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis
Email: khonina@ios.uran.ru
Россия, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
E. Shadrina
Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis
Email: khonina@ios.uran.ru
Россия, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
E. Nikitin
Ural Branch of the Russian Academy of Sciences, I. Ya. Postovsky Institute of Organic Synthesis
Email: khonina@ios.uran.ru
Россия, 22 ul. S. Kovalevskoi, Ekaterinburg, 620990
L. Larionov
Ministry of Health of the Russian Federation, Ural State Medical University
Email: khonina@ios.uran.ru
Россия, 3 ul. Repina, Ekaterinburg, 620219