Отправить статью по E-mail Inhibition of acid phospholipase A1 activity by the complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate)
- Авторы: Abzaeva K.A.1, Rasulov M.M.2, Zhigacheva I.V.3
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Учреждения:
- A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
- State Research Institute of Chemistry and Technology of Organoelement Compounds
- N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
- Выпуск: Том 68, № 5 (2019)
- Страницы: 1122-1124
- Раздел: Brief Communications
- URL: https://journals.rcsi.science/1066-5285/article/view/243390
- DOI: https://doi.org/10.1007/s11172-019-2529-9
- ID: 243390
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Аннотация
Studies in the atherosclerosis model in rabbits showed that the complex of tris(2-hydroxyethyl)amine with zinc bis(2-methylphenoxyacetate) (zincatrane) modulates lipid metabolism in the liver and reduces activity of a lysosomal lipolytic enzyme of the hydrolase class. Zincatrane was proposed for use as an acid phospholipase A1 inhibitor to increase the resistance of the vascular system to cholesterol and prevent atherosclerosis.
Об авторах
K. Abzaeva
A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: abzaeva@irioch.irk.ru
Россия, 1 ul. Favorskogo, Irkutsk, 664033
M. Rasulov
State Research Institute of Chemistry and Technology of Organoelement Compounds
Email: abzaeva@irioch.irk.ru
Россия, 38 Entuziastov shosse, Moscow, 105118
I. Zhigacheva
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences
Email: abzaeva@irioch.irk.ru
Россия, 4 ul. Kosygina, Moscow, 119334
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