Synthesis of (1S)-(+)-camphor-10-sulfonic acid derivatives and investigations in vitro and in silico of their antiviral activity as the inhibitors of fi lovirus infections
- Авторы: Sokolova A.1, Baranova D.1,2, Yarovaya O.1,2, Baev D.1,2, Polezhaeva O.3, Zybkina A.3, Shcherbakov D.3, Tolstikova T.1,2, Salakhutdinov N.1,2
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Учреждения:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State University
- State Research Center of Virology and Biotechnology “Vector”
- Выпуск: Том 68, № 5 (2019)
- Страницы: 1041-1046
- Раздел: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243378
- DOI: https://doi.org/10.1007/s11172-019-2517-0
- ID: 243378
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Аннотация
N-Heterocycle-containing (1S)-(+)-camphor-10-sulfonamide derivatives were synthesized. Their antiviral activity against the Ebola and Marburg viruses was estimated using a pseudovirus system based on the vesicular stomatitis virus. The derivatives bearing morpholine and triazole moieties demonstrated the highest inhibitory activity towards the Ebola virus glycoprotein. A moderate activity against the Marburg virus was found for a compound containing the piperidine moiety. A molecular modeling of the interaction between the synthesized derivatives and the binding site of glycoprotein of the Ebola virus was performed.
Об авторах
A. Sokolova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
Автор, ответственный за переписку.
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090
D. Baranova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
O. Yarovaya
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
D. Baev
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
O. Polezhaeva
State Research Center of Virology and Biotechnology “Vector”
Email: asokolova@nioch.nsc.ru
Россия, Koltsovo, Novosibirsk Region, 630559
A. Zybkina
State Research Center of Virology and Biotechnology “Vector”
Email: asokolova@nioch.nsc.ru
Россия, Koltsovo, Novosibirsk Region, 630559
D. Shcherbakov
State Research Center of Virology and Biotechnology “Vector”
Email: asokolova@nioch.nsc.ru
Россия, Koltsovo, Novosibirsk Region, 630559
T. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090
N. Salakhutdinov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences; Novosibirsk State University
Email: asokolova@nioch.nsc.ru
Россия, 9 prosp. Akad. Lavrent’eva, Novosibirsk, 630090; 2 ul. Pirogova, Novosibirsk, 630090