Enviar artigo por via de e-mail Reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides with hydroxylamine and biological activity of the products
- Autores: Pulina N.A.1, Sobin F.V.1, Yushkova T.A.1, Novikova V.V.1
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Afiliações:
- Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
- Edição: Volume 68, Nº 3 (2019)
- Páginas: 628-633
- Seção: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243327
- DOI: https://doi.org/10.1007/s11172-019-2466-7
- ID: 243327
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Resumo
The reactions of 4-aryl-N-hetaryl-2-hydroxy-4-oxobut-2-enamides (hetaryl is 2-pyridyl, 2-azolyls, benzo[d]thiazol-2-yl) with hydroxylamine yielded 4-aryl-N-hetaryl-2-hydroxyimino-4-oxobutanamides and 5-aryl-N-hetarylisoxazole-3-carboxamides. The products were searched for representatives with high antimicrobial and anti-inflammatory activities and low acute toxicity. A structure—pharmacological activity relationship of the prepared compounds was established.
Sobre autores
N. Pulina
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Autor responsável pela correspondência
Email: pulina-nata@mail.ru
Rússia, 2 ul. Polevaya, Perm, 614990
F. Sobin
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Rússia, 2 ul. Polevaya, Perm, 614990
T. Yushkova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Rússia, 2 ul. Polevaya, Perm, 614990
V. Novikova
Perm State Pharmaceutical Academy, Ministry of Health of the Russian Federation
Email: pulina-nata@mail.ru
Rússia, 2 ul. Polevaya, Perm, 614990
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