Diastereoselective multicomponent synthesis of (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates
- Авторы: Vereshchagin A.1, Karpenko K.1, Iliyasov T.1, Elinson M.1, Dorofeeva E.1, Fakhrutdinov A.1, Egorov M.1
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Учреждения:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Выпуск: Том 67, № 11 (2018)
- Страницы: 2049-2053
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/243174
- DOI: https://doi.org/10.1007/s11172-018-2327-9
- ID: 243174
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Аннотация
Multicomponent reaction of benzylidenemalononitrile, 2-acetyl-3-arylacrylates, and aqueous ammonia in alcohols at room temperature proceeds stereoselectively to give (4RS,6SR)-4,6-diaryl-5,5-dicyano-2-methyl-1,4,5,6-tetrahydropyridine-3-carboxylates in 55–87% yields. In this reaction, ammonia acts as both the catalyst and the source of nitrogen for constructing tetrahydropyridine cycle.
Об авторах
A. Vereshchagin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Автор, ответственный за переписку.
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
K. Karpenko
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
T. Iliyasov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
M. Elinson
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
E. Dorofeeva
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
A. Fakhrutdinov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991
M. Egorov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: vereshchagin@ioc.ac.ru
Россия, 47 Leninsky prosp., Moscow, 119991