Synthesis and properties of 1-(R-adamant-1-yl)-3-(1-propionylpiperidin-4-yl)ureas and 4-({4-[3-(R-adamant-1-yl)ureido]cyclohexyl}oxy)benzoic acids, efficient target-oriented human soluble epoxide hydrolase inhibitors
- Авторы: Butov G.1, Burmistrov V.1, Danilov D.1
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Учреждения:
- Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
- Выпуск: Том 66, № 10 (2017)
- Страницы: 1876-1880
- Раздел: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/241447
- DOI: https://doi.org/10.1007/s11172-017-1961-y
- ID: 241447
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Аннотация
A reaction of R-adamant-1-yl isocyanates with 4-[(4-aminocyclohexyl)oxy]benzoic acid and 1-(4-aminopiperidin-1-yl)propan-1-one in DMF afforded corresponding ureas in 90—95% yield, the target-oriented inhibitors of epoxide hydrolase sEH. The ureas are characterized by reduced melting points and increased solubility in water, as well as by inhibitory activity in the range of 0.5—4.0 nmol L–1.
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G. Butov
Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
Автор, ответственный за переписку.
Email: butov@volpi.ru
Россия, 42a ul. Engelsa, Volzhsky, 404121
V. Burmistrov
Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
Email: butov@volpi.ru
Россия, 42a ul. Engelsa, Volzhsky, 404121
D. Danilov
Volzhsky Polytechnical Institute (branch) of the Volgograd State Technical University
Email: butov@volpi.ru
Россия, 42a ul. Engelsa, Volzhsky, 404121