Enviar artigo por via de e-mail Synthesis and antimycobacterial activity of N-isonicotinoyl-N′-alkylideneferrocenecarbohydrazides
- Autores: Nikulin R.S.1,2, Rodionov A.N.1, Babusenko E.S.2, Babin V.N.1, Kovalenko L.V.2, Belousov Y.A.1, Kulikov V.N.1,2
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Afiliações:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- D. I. Mendeleev University of Chemical Technology of Russia
- Edição: Volume 66, Nº 6 (2017)
- Páginas: 1122-1125
- Seção: Full Articles
- URL: https://journals.rcsi.science/1066-5285/article/view/240884
- DOI: https://doi.org/10.1007/s11172-017-1864-y
- ID: 240884
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Resumo
Acylation of ferrocenoylhydrazones with isonicotinoyl chloride hydrochloride in pyridine was used to obtain a number of new N-isonicotinoyl-N′-ylideneferrocenecarbohydrazides in 50–95% yields. The obtained compounds were characterized by NMR and IR spectroscopy and mass-spectrometry. Some of the obtained compounds were found to exhibit pronounced antimycobacterial activity against the Mycobacterium rubrum strain and to have no toxicity with respect to the P. aeruginosa, E. coli, S. aureus, B. subtilis, and C. albicans strains.
Sobre autores
R. Nikulin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
A. Rodionov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
E. Babusenko
D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Rússia, 9 Miusskaya pl., Moscow, 125047
V. Babin
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: belur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
L. Kovalenko
D. I. Mendeleev University of Chemical Technology of Russia
Email: belur@ineos.ac.ru
Rússia, 9 Miusskaya pl., Moscow, 125047
Yu. Belousov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Autor responsável pela correspondência
Email: belur@ineos.ac.ru
Rússia, 28 ul. Vavilova, Moscow, 119991
V. Kulikov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia
Autor responsável pela correspondência
Email: kulikov_v_n@mail.ru
Rússia, 28 ul. Vavilova, Moscow, 119991; 9 Miusskaya pl., Moscow, 125047
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