6-Trifluoromethyl-2-thiouracil and its analogs in reactions with 4-bromobutyl acetate and 2-bromoacetophenone
- Авторлар: Ezhikova M.1, Kodess M.1,2, Ulitko M.2, Saloutin V.1,2, Ivanova A.1, Khudina O.1, Burgart Y.1,2, Pervova M.1
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Мекемелер:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Шығарылым: Том 68, № 6 (2019)
- Беттер: 1190-1195
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/243399
- DOI: https://doi.org/10.1007/s11172-019-2538-8
- ID: 243399
Дәйексөз келтіру
Аннотация
The alkylation of 6-(polyfluoro)alkyl-2-thiouracils with 4-bromobutyl acetate in refluxing acetonitrile in the presence of K2CO3 proceeds regioselectively to give S, O-disubstituted pyrimidines as the major products and S,N-isomers as the minor ones, whereas the use of 2-bromoacetophenone as an alkylating agent results in the formation of the S,O-isomer. 6-Trifluoromethyl-2-thiouracil and 2-(2-oxo-2-phenylethylthio)-4-(2-oxo-2-phenylethoxy)-6-trifluoromethyl-pyrimidine exhibited marked tuberculostatic activity. 6-Trifluoromethyl-2-thiouracil did not exert a significant cytotoxic effect on the HeLa cell culture and human dermal fibroblasts.
Авторлар туралы
M. Ezhikova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990
M. Kodess
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
M. Ulitko
Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: saloutin@ios.uran.ru
Ресей, 19 ul. Mira, Yekaterinburg, 620002
V. Saloutin
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Хат алмасуға жауапты Автор.
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
A. Ivanova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990
O. Khudina
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990
Ya. Burgart
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990; 19 ul. Mira, Yekaterinburg, 620002
M. Pervova
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: saloutin@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Yekaterinburg, 620990