Synthesis and biological activity of arylaliphatic  N -(2-aminoethyl)- N -(2-hydroxy-2-phenylethyl)carboxamides

D. Q. Hoang; E. Ya. Borisova; N. Yu. Borisova; N. Yu. Asilova; O. S. Kaldyrkaeva; E. V. Arzamastsev; O. A. Terekhova; E. Yu. Afanas’eva; E. L. Levitskaya

doi:10.1007/s11172-018-2048-0

Synthesis and biological activity of arylaliphatic N-(2-aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides

Авторлар: Hoang D.Q.¹, Borisova E.Y.¹, Borisova N.Y.¹, Asilova N.Y.¹, Kaldyrkaeva O.S.², Arzamastsev E.V.², Terekhova O.A.², Afanas’eva E.Y.², Levitskaya E.L.²
Мекемелер:
1. Moscow Technological University (Institute of Fine Chemical Technology)
2. Russian Cardiology Research and Production Complex
Шығарылым: Том 67, № 1 (2018)
Беттер: 131-136
Бөлім: Article
URL: https://journals.rcsi.science/1066-5285/article/view/241982
DOI: https://doi.org/10.1007/s11172-018-2048-0
ID: 241982

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Аннотация

N-(2-Aminoethyl)-N-(2-hydroxy-2-phenylethyl)carboxamides were synthesized from styrene oxide by ring opening with N,N-disubstituted ethylenediamines followed by N-acylation. Synthesized compounds have pronounced antiarrhythmic activity and low toxicity.

Негізгі сөздер

styrene oxide, ethylenediamine, diamino alcohols, amino amides, acylation, arrhythmia, biological activity

Авторлар туралы

D. Hoang

Moscow Technological University (Institute of Fine Chemical Technology)

Хат алмасуға жауапты Автор.
Email: quanghoang1510@gmail.com
Ресей, 86 prosp. Vernadskogo, Moscow, 119571

E. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
Ресей, 86 prosp. Vernadskogo, Moscow, 119571

N. Borisova

Moscow Technological University (Institute of Fine Chemical Technology)

Email: quanghoang1510@gmail.com
Ресей, 86 prosp. Vernadskogo, Moscow, 119571