Differences in reactivity of N-acetyl- and N,N-diacetylsialyl chlorides caused by their different supramolecular organization in solutions
- Авторлар: Bovin N.1, Kononov L.2, Orlova A.2, Laptinskaya T.3
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Мекемелер:
- M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- Department of Physics, M. V. Lomonosov Moscow State University
- Шығарылым: Том 66, № 11 (2017)
- Беттер: 2173-2179
- Бөлім: Full Article
- URL: https://journals.rcsi.science/1066-5285/article/view/241696
- DOI: https://doi.org/10.1007/s11172-017-1999-x
- ID: 241696
Дәйексөз келтіру
Аннотация
O-Sialylation of a substituted indolin-3-one under phase-transfer catalysis conditions, which does not occur when N-acetylsialyl chloride is used, proceeds with N,N-diacetylsialyl chloride as the glycosyl donor. A study using dynamic light scattering of solutions of both sialyl chlorides under conditions close to the conditions used for glycosylation showed a difference in the correlation radii of light scattering particles in such solutions. This suggests that the introduction of an additional N-acetyl group into the sialyl chloride significantly alters the structure of the supramers of glycosyl donor, which apparently have an increased accessibility of individual molecules for the attack by a nucleophile, which increases its reactivity.
Авторлар туралы
N. Bovin
M. M. Shemyakin and Yu. A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: kononov@ioc.ac.ru
Ресей, 16/10 ul. Miklukho-Maklaya, Moscow, 117997
L. Kononov
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: kononov@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
A. Orlova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: kononov@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991
T. Laptinskaya
Department of Physics, M. V. Lomonosov Moscow State University
Email: kononov@ioc.ac.ru
Ресей, Build. 2, 1 Leninskie Gory, Moscow, 119991