New possibilities of the Mannich reaction in the synthesis of N-, S,N-, and Se,N-heterocycles
- Authors: Dotsenko V.V.1,2,3, Frolov K.A.3,4, Chigorina E.A.5, Khrustaleva A.N.3, Bibik E.Y.4, Krivokolysko S.G.3,4
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Affiliations:
- Kuban State University
- North-Caucasus Federal University
- Scientific Research Laboratory “Khimeks”, Vladimir Dal’Lugansk National University
- Lugansk State Medical University named after St. Luke (Voino-Yasenetsky)
- State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances, National Research Centre “Kurchatov Institute”
- Issue: Vol 68, No 4 (2019)
- Pages: 691-707
- Section: Review
- URL: https://journals.rcsi.science/1066-5285/article/view/243337
- DOI: https://doi.org/10.1007/s11172-019-2476-5
- ID: 243337
Cite item
Abstract
The review summarizes the results obtained by our research group over the past 15 years in chemistry of N-, S,N-, and Se,N-heterocycles resulted from aminomethlation of a wide range of acyclic and heterocyclic substrates derived from active methylene amides, thioamides, and selenoamides. A series of 1,3,5-thia(selena)diazines, 3,7-diazabicyclo[3.3.1] nonanes, 3,5,7,11-tetraazatricyclo[7.3.1.02,7]tridec-2-enes, 1,3,5,7-tetrazocines, and pyrido[1,2-a][1,3,5]triazines were synthesized. The general regularities of the Mannich reaction in the series of N-, S,N-, and Se,N-containing pyridine substrates were discussed. Biological activities of some synthesized compounds were studied to reveal compounds with antiviral, analeptic, anti-inflammatory, and antipyretic activities.
About the authors
V. V. Dotsenko
Kuban State University; North-Caucasus Federal University; Scientific Research Laboratory “Khimeks”, Vladimir Dal’Lugansk National University
Author for correspondence.
Email: victor_dotsenko_@mail.ru
Russian Federation, 149 ul. Stavropol’skaya, Krasnodar, 350040; 1A ul. Pushkina, Stavropol’, 355009; 20a, Build. 7, quarter Molodezhnyi, Lugansk, 91034
K. A. Frolov
Scientific Research Laboratory “Khimeks”, Vladimir Dal’Lugansk National University; Lugansk State Medical University named after St. Luke (Voino-Yasenetsky)
Email: victor_dotsenko_@mail.ru
Ukraine, 20a, Build. 7, quarter Molodezhnyi, Lugansk, 91034; 1g quarter 50-Letiya Oborony Luganska, Lugansk, 91045
E. A. Chigorina
State Scientific-Research Institute of Chemical Reagents and High Purity Chemical Substances, National Research Centre “Kurchatov Institute”
Email: victor_dotsenko_@mail.ru
Russian Federation, 3 Bogorodskii Val, Moscow, 107076
A. N. Khrustaleva
Scientific Research Laboratory “Khimeks”, Vladimir Dal’Lugansk National University
Email: victor_dotsenko_@mail.ru
Ukraine, 20a, Build. 7, quarter Molodezhnyi, Lugansk, 91034
E. Yu. Bibik
Lugansk State Medical University named after St. Luke (Voino-Yasenetsky)
Email: victor_dotsenko_@mail.ru
Ukraine, 1g quarter 50-Letiya Oborony Luganska, Lugansk, 91045
S. G. Krivokolysko
Scientific Research Laboratory “Khimeks”, Vladimir Dal’Lugansk National University; Lugansk State Medical University named after St. Luke (Voino-Yasenetsky)
Email: victor_dotsenko_@mail.ru
Ukraine, 20a, Build. 7, quarter Molodezhnyi, Lugansk, 91034; 1g quarter 50-Letiya Oborony Luganska, Lugansk, 91045