Email this article Photodynamic damage to erythrocytes and liposomes sensitized by chlorophyll a derivatives
- Authors: Belykh D.V.1, Shevchenko O.G.2, Firsov A.M.3, Kotova E.A.3, Khudyaeva I.S.1, Plyusnina S.N.2, Antonenko Y.N.3
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Affiliations:
- Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
- A. N. Belozersky Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University
- Issue: Vol 67, No 8 (2018)
- Pages: 1513-1517
- Section: Article
- URL: https://journals.rcsi.science/1066-5285/article/view/242883
- DOI: https://doi.org/10.1007/s11172-018-2249-6
- ID: 242883
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Abstract
A comparative study of photohemolysis of erythrocytes and photodamage to liposomes sensitized by the chlorophyll a derivatives is reported. The photomodification of liposomes was assessed by the degree of leakage of sulforhodamine B, whereas hemolysis was measured by the release of hemoglobin. A statistically significant positive correlation between the degree of photohemolysis of erythrocytes and the degree of photodamage to liposomes was found. The correlation observed suggests that the photoinduced loss of lipid bilayer integrity is the main mechanism of photodegradation of erythrocyte membranes in the case of the photosensitizers studied.
About the authors
D. V. Belykh
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: belykh-dv@mail.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167982
O. G. Shevchenko
Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: belykh-dv@mail.ru
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
A. M. Firsov
A. N. Belozersky Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University
Email: belykh-dv@mail.ru
Russian Federation, 1/73 Leninskie Gory, Moscow, 119991
E. A. Kotova
A. N. Belozersky Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University
Email: belykh-dv@mail.ru
Russian Federation, 1/73 Leninskie Gory, Moscow, 119991
I. S. Khudyaeva
Institute of Chemistry, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: belykh-dv@mail.ru
Russian Federation, 48 ul. Pervomaiskaya, Syktyvkar, 167982
S. N. Plyusnina
Institute of Biology, Komi Scientific Center, Ural Branch of the Russian Academy of Sciences
Email: belykh-dv@mail.ru
Russian Federation, 28 ul. Kommunisticheskaya, Syktyvkar, 167982
Y. N. Antonenko
A. N. Belozersky Institute of Physicochemical Biology, M. V. Lomonosov Moscow State University
Email: belykh-dv@mail.ru
Russian Federation, 1/73 Leninskie Gory, Moscow, 119991
