Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives

T. N. T. Nguyen; A. G. Iksanova; O. A. Lodochnikova; Yu. G. Shtyrlin; M. V. Pugachev; R. S. Pavelyev

doi:10.1007/s11172-016-1333-z

Synthesis and antitumor activity of pyridoxine monoalkenyl derivatives

Authors: Nguyen T.N.¹, Iksanova A.G.¹, Lodochnikova O.A.², Shtyrlin Y.G.¹, Pugachev M.V.¹, Pavelyev R.S.¹
Affiliations:
1. Research and Education Center of Pharmacy, Kazan (Volga region) Federal University
2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center of the Russian Academy of Sciences
Issue: Vol 65, No 2 (2016)
Pages: 532-536
Section: Full Articles
URL: https://journals.rcsi.science/1066-5285/article/view/237253
DOI: https://doi.org/10.1007/s11172-016-1333-z
ID: 237253

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Abstract

A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium chloride with aldehydes was suggested. Some of the compounds obtained exhibit antitumor activity in vitro.