Synthesis of a Potential Tumor Imaging Agent by Oxidative Radioiodination of Aspirin and Its Preclinical Study
- 作者: Ibrahim I.1, Attallah K.1,2, Elsaid M.3, Fahmy M.1, Abo Zaid L.4
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隶属关系:
- Hot Laboratories Centre
- Pharmaceutics Department, Faculty of Pharmacy
- Biochemistry Department, Faculty of Pharmacy
- Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy
- 期: 卷 61, 编号 2 (2019)
- 页面: 220-225
- 栏目: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/225080
- DOI: https://doi.org/10.1134/S1066362219020152
- ID: 225080
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Aspirin, one of nonsteroidal anti-inflammatory analgesic drugs, was labeled with 125I with a labeling yield of 85.5% under the following conditions: pH 9, 100 mg of the substrate, 50 µg of Chloramine-T, 5–15 min, room temperature. The radiochemical yield of 125I-aspirin was determined by paper chromatography and electrophoresis, and the radiochemical purity was determined by HPLC.125I-aspirin was stable for at least 3 h. Biodistribution of 125I-aspirin in normal and tumor-bearing mice was studied. The uptake of 125I-aspirin in tumor sites makes it promising as a new radiopharmaceutical for tumor imaging.
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作者简介
I. Ibrahim
Hot Laboratories Centre
编辑信件的主要联系方式.
Email: ismailtaha_73@yahoo.com
埃及, Cairo
K. Attallah
Hot Laboratories Centre; Pharmaceutics Department, Faculty of Pharmacy
Email: ismailtaha_73@yahoo.com
埃及, Cairo; Mecca
M. Elsaid
Biochemistry Department, Faculty of Pharmacy
Email: ismailtaha_73@yahoo.com
沙特阿拉伯, Buraydah
M. Fahmy
Hot Laboratories Centre
Email: ismailtaha_73@yahoo.com
埃及, Cairo
L. Abo Zaid
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy
Email: ismailtaha_73@yahoo.com
埃及, Mansoura; Gumassa