Radioiodination and biological evaluation of rabeprazole as a peptic ulcer localization radiotracer
- 作者: Sanad M.1, Challan S.2
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隶属关系:
- Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division
- Nuclear Physics Department, Cyclotrone Project
- 期: 卷 59, 编号 3 (2017)
- 页面: 307-312
- 栏目: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/223972
- DOI: https://doi.org/10.1134/S1066362217030158
- ID: 223972
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Rabeprazole, a proton pump inhibitor, was labeled with 131I to give 131I-rabeprazole in 98% yield. The optimum conditions were as follows: pH 8, 100 μg of chloramine-T, 30 min, and 0.2 mg of rabeprazole. The labeled compound was stable for 24 h. Biodistribution of 131I-rabeprazole in mice after intravenous injection was studied, and its high uptake in stomach ulcer, reaching approximately 38% ID/g at 1 h post injection, was demonstrated. This concentration of the labeled compound in stomach ulcer is sufficient for ulcer imaging. The advantages of the method are simple labeling procedure, high labeling yield, and high sensitivity of ulcer imaging.
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作者简介
M. Sanad
Labeled Compounds Department, Radioisotopes Production and Radioactive Sources Division
编辑信件的主要联系方式.
Email: msanad74@yahoo.com
埃及, Cairo
S. Challan
Nuclear Physics Department, Cyclotrone Project
Email: msanad74@yahoo.com
埃及, Cairo