Synthesis and Preliminary Biological Evaluation of 99mTc Tricarbonyl Ropinirole as a Potential Brain Imaging Agent
- Авторы: Sanad M.1, Rizvi F.2, Kumar R.3, Ibrahim A.4
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Учреждения:
- Labeled Compounds Department, Hot Laboratories Center
- Department of Chemistry
- Centre for Nuclear Medicine
- Applied Organic Chemistry Deptartment, Organic Chemical Industries Division
- Выпуск: Том 61, № 6 (2019)
- Страницы: 754-758
- Раздел: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/225400
- DOI: https://doi.org/10.1134/S1066362219060195
- ID: 225400
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Аннотация
Ropinirole, a non-ergoline dopamine agonist, was labeled with 99mTc tricarbonyl {[99mTc(CO)3·(H2O)3]+} with the aim of obtaining a new brain imaging agent. For in vivo use, the radiosynthesis of 99mTc tricarbonyl ropinirole was performed by heating a solution containing ropinirole and the precursor, 99mTc tricarbonyl, on a boiling water bath for 30 min. The influence of the substrate amount and pH on the reaction was studied to optimize the synthesis. The biodistribution and scintigraphic studies demonstrate the suitability of 99mTc tricarbonyl ropinirole as a novel tracer for brain tumor imaging.
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Об авторах
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
Email: askarifaheem@gmail.com
Египет, Cairo
F. Rizvi
Department of Chemistry
Автор, ответственный за переписку.
Email: askarifaheem@gmail.com
Пакистан, Faisalabad
R. Kumar
Centre for Nuclear Medicine
Email: askarifaheem@gmail.com
Индия, Chandigarh
A. Ibrahim
Applied Organic Chemistry Deptartment, Organic Chemical Industries Division
Email: askarifaheem@gmail.com
Египет, Cairo