99mTc-Oxiracetam as a Potential Agent for Diagnostic Imaging of Brain: Labeling, Characterization, and Biological Evaluation
- Авторлар: Sanad M.1, Sallam K.1, Salama D.2
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Мекемелер:
- Labeled Compounds Department, Hot Laboratories Center
- Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
- Шығарылым: Том 60, № 1 (2018)
- Беттер: 58-63
- Бөлім: Article
- URL: https://journals.rcsi.science/1066-3622/article/view/224355
- DOI: https://doi.org/10.1134/S1066362218010101
- ID: 224355
Дәйексөз келтіру
Аннотация
Oxiracetam was labeled with 99mTc using sodium dithionite (Na2S2O4) as a reducing agent. The influence exerted on the labeling yield by the amounts of the reducing agent and substrate, pH, temperature, and reaction time was studied to optimize the labeling process. Biodistribution studies show that the 99mTcoxiracetam complex is suitable as a highly selective tracer for brain imaging.
Негізгі сөздер
Авторлар туралы
M. Sanad
Labeled Compounds Department, Hot Laboratories Center
Хат алмасуға жауапты Автор.
Email: drsanad74@gmail.com
Египет, Cairo
Kh. Sallam
Labeled Compounds Department, Hot Laboratories Center
Email: drsanad74@gmail.com
Египет, Cairo
D. Salama
Health Radiation Research Department (Radiodiagnosis Unit), National Center for Radiation Research and Technology
Email: drsanad74@gmail.com
Египет, Cairo