Mathematical simulation of complex formation of protein molecules allowing for their domain structure
- Авторы: Koshlan T.1, Kulikov K.2
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Учреждения:
- St. Petersburg State University
- Peter the Great St. Petersburg Polytechnic University
- Выпуск: Том 62, № 4 (2017)
- Страницы: 509-516
- Раздел: Theoretical and Mathematical Physics
- URL: https://journals.rcsi.science/1063-7842/article/view/199186
- DOI: https://doi.org/10.1134/S1063784217040119
- ID: 199186
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Аннотация
A physical model of the interactions between protein molecules has been presented and an analysis of their propensity to form complex biological complexes has been performed. The reactivities of proteins have been studied using electrostatics methods based on the example of the histone chaperone Nap1 and histones H2A and H2B. The capability of proteins to form stable biological complexes that allow for different segments of amino acid sequences has been analyzed. The ability of protein molecules to form compounds has been considered by calculating matrices of electrostatic potential energy of amino acid residues constituting the polypeptide chain. The method of block matrices has been used in the analysis of the ability of protein molecules to form complex biological compounds.
Об авторах
T. Koshlan
St. Petersburg State University
Email: kulikov.kirill.g@gmail.com
Россия, St. Petersburg, 199034
K. Kulikov
Peter the Great St. Petersburg Polytechnic University
Автор, ответственный за переписку.
Email: kulikov.kirill.g@gmail.com
Россия, St. Petersburg, 195251