Comparative Study of Polymer Nanoparticles on the Basis of Caprolactone–Polyvinyl Alcohol Mixtures with an Encapsulated Antitumor Preparation by Atomic Force Microscopy, X-Ray Diffraction, and Dynamic Light Scattering
- Авторы: Sukhanova T.1,2, Vylegzhanina M.1, Volkov A.1, Gasilova E.1, Kutin A.1, Samy M.3, Abdallah H.3, Ayoub M.3
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Учреждения:
- Institute of Macromolecular Compounds, Russian Academy of Sciences
- Lebedev Research Institute of Synthetic Rubber
- Department of Polymers and Pigments, National Research Center
- Выпуск: Том 64, № 12 (2019)
- Страницы: 1729-1737
- Раздел: 23rd INTERNATIONAL SYMPOSIUM “NANOPHYSICS AND NANOELECTRONICS,” Nizhny Novgorod, March 11–14, 2019
- URL: https://journals.rcsi.science/1063-7842/article/view/204827
- DOI: https://doi.org/10.1134/S1063784219120235
- ID: 204827
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Аннотация
The morphology, structure, and optical properties of composites with biodegradable polymeric particles, which are based on poly-ε-caprolactone–polyvinyl alcohol (stabilizer) mixtures and contain 5-Fluorouracil (an antitumor preparation), have been studied by atomic-force and optical microscopy, X-ray diffraction, and dynamic and static light scattering. Studies have shown that the morphology of synthesized composites sustains appreciable transformations depending on their stabilizer content. No crystalline reflections corresponding to 5-Fluorouracil have been revealed, thus arguing for a high dispersity of this preparation in the polymeric matrix of caprolactone. The correlations between the structural and morphological parameters, composition, stabilizer concentration and the efficiency of the encapsulation of 5-Fluorouracil by the composites have been established.
Об авторах
T. Sukhanova
Institute of Macromolecular Compounds, Russian Academy of Sciences; Lebedev Research Institute of Synthetic Rubber
Автор, ответственный за переписку.
Email: tat_sukhanova@bk.ru
Россия, St. Petersburg, 199004; St. Petersburg, 198035
M. Vylegzhanina
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Россия, St. Petersburg, 199004
A. Volkov
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Россия, St. Petersburg, 199004
E. Gasilova
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Россия, St. Petersburg, 199004
A. Kutin
Institute of Macromolecular Compounds, Russian Academy of Sciences
Email: tat_sukhanova@bk.ru
Россия, St. Petersburg, 199004
Moshera Samy
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Египет, Dokki, Giza, Cairo, 12622
Heba Abdallah
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Египет, Dokki, Giza, Cairo, 12622
Magdy Ayoub
Department of Polymers and Pigments, National Research Center
Email: tat_sukhanova@bk.ru
Египет, Dokki, Giza, Cairo, 12622