Synthesis, Spectroscopy, and α-Glucosidase Inhibitory Activity of 3-Substituted Hydrazone Derivatives and Crystal Structure of (1E,2E)-1,2-Bis[1-(3-methoxyphenyl)ethylidene]hydrazone
- Авторлар: Boonnak N.1, Chantrapromma S.2, Ruanwas P.2, Sontimuang C.3, Fun H.4
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Мекемелер:
- Department of Basic Science and Mathematics, Faculty of Science
- Department of Chemistry, Faculty of Science
- Faculty of Traditional Thai Medicine
- X-ray Crystallography Unit, School of Physics
- Шығарылым: Том 62, № 7 (2017)
- Беттер: 1104-1108
- Бөлім: Structure of Organic Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/191767
- DOI: https://doi.org/10.1134/S1063774517070069
- ID: 191767
Дәйексөз келтіру
Аннотация
Six 3-substituted hydrazone derivatives [R = −OCH3 (1), −NH2 (2), −NO2 (3), −F (4), −Cl (5), and −Br (6)] were synthesized by condensation reaction. Their structures were elucidated by 1H NMR, FT-IR and UV-Vis spectroscopy. The synthesized compounds were further evaluated for their α-glucosidase inhibitory activity. Strong activity was found for 1 and 3. The crystal structure of 1 was determined by single crystal X-ray diffraction: a = 6.9743(1) Å, b = 18.3627(3) Å, c = 12.0207(2) Å, β = 96.087(1)o, sp. gr. P21/c, Z = 4. The molecule of 1 is twisted with the dihedral angle between the two phenyl rings being 51.91(4)°. In the crystal packing, the molecules are linked into chains by C–H···π interactions.
Авторлар туралы
N. Boonnak
Department of Basic Science and Mathematics, Faculty of Science
Хат алмасуға жауапты Автор.
Email: nawongb@yahoo.com
Таиланд, Songkhla
S. Chantrapromma
Department of Chemistry, Faculty of Science
Хат алмасуға жауапты Автор.
Email: suchada.c@psu.ac.th
Таиланд, Hat Yai
P. Ruanwas
Department of Chemistry, Faculty of Science
Email: suchada.c@psu.ac.th
Таиланд, Hat Yai
C. Sontimuang
Faculty of Traditional Thai Medicine
Email: suchada.c@psu.ac.th
Таиланд, Hat Yai
H.-K. Fun
X-ray Crystallography Unit, School of Physics
Email: suchada.c@psu.ac.th
Таиланд, Penang