Modified 5-fluorouracil: Uridine phosphorylase inhibitor
- Авторлар: Lashkov A.1, Shchekotikhin A.2, Shtil A.3, Sotnichenko S.1, Mikhailov A.1
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Мекемелер:
- Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics”
- Gause Institute of New Antibiotics
- Blokhin Russian Cancer Research Center
- Шығарылым: Том 61, № 5 (2016)
- Беттер: 826-829
- Бөлім: Structure of Macromolecular Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/190309
- DOI: https://doi.org/10.1134/S1063774516050138
- ID: 190309
Дәйексөз келтіру
Аннотация
5-Fluorouracil (5-FU) is a medication widely used in chemotherapy to treat various types of cancer. Being a substrate for the reverse reaction catalyzed by uridine phosphorylase (UPase), 5-FU serves as a promising prototype molecule (molecular scaffold) for the design of a selective UPase inhibitor that enhances the antitumor activity of 5-FU and exhibits intrinsic cytostatic effects on cancer cells. The chemical formula of the new compound, which binds to the uracil-binding site and, in the presence of a phosphate anion, to the phosphate-binding site of UPase, is proposed and investigated by molecular simulation methods.
Авторлар туралы
A. Lashkov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics”
Хат алмасуға жауапты Автор.
Email: alashkov83@gmail.com
Ресей, Leninskii pr. 59, Moscow, 119333
A. Shchekotikhin
Gause Institute of New Antibiotics
Email: alashkov83@gmail.com
Ресей, ul. Bol’shaya Pirogovskaya 11, Moscow, 119021
A. Shtil
Blokhin Russian Cancer Research Center
Email: alashkov83@gmail.com
Ресей, Kashirskoe sh. 23, Moscow, 115478
S. Sotnichenko
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics”
Email: alashkov83@gmail.com
Ресей, Leninskii pr. 59, Moscow, 119333
A. Mikhailov
Shubnikov Institute of Crystallography of Federal Scientific Research Centre “Crystallography and Photonics”
Email: alashkov83@gmail.com
Ресей, Leninskii pr. 59, Moscow, 119333