Crystal Structure of Zinc(II) Complexes with 2-Ethyl-3-hydroxy-4H-pyran-4-thione and 2-Ethyl-3-hydroxy-4H-pyran-4-selenone
- 作者: Takayuki Nishiguchi 1, Yamashita M.2, Yoshikawa Y.3, Yasui H.1
-
隶属关系:
- Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku
- Department of Pharmaceutical Manufacturing Chemistry, Division of Medicinal Chemical Sciences, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku
- Department of Health, Sports, and Nutrition, Faculty of Health and Welfare, Kobe Women’s University, 4-7-2 Minatojima-nakamachi, Chuo-ku
- 期: 卷 64, 编号 7 (2019)
- 页面: 1099-1102
- 栏目: Structure of Organic Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/194474
- DOI: https://doi.org/10.1134/S1063774519070150
- ID: 194474
如何引用文章
详细
Zn(II) complexes with 2-ethyl-3-hydroxy-4H-pyran-4-thione, [Zn(ehpt)2], and 2-ethyl-3-hydroxy-4H-pyran-4-selenone, [Zn(ehps)2], were synthesized and characterized by single crystal X-ray diffraction. Complexes are isostructural, crystallize in sp. gr. P21/n with Z = 4. The Zn2+ ion has a distorted tetrahedral coordination with two S or Se atoms and two O atoms from ehpt or ehps, respectively. In vitro, insulin-mimetic activities of [Zn(ehpt)2] and [Zn(ehps)2] are much higher than that of Zn complex with maltol, 3-hydroxy-2-methyl-4H-pyran-4-one, [Zn(hmpo)2]}, where Zn coordination is completed by H2O molecules. It suggests that Zn complexes with distorted tetrahedral coordination might exhibit higher insulin-mimetic activities than those with octahedral or square pyramidal coordination.
作者简介
Takayuki Nishiguchi
Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences,Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku
Email: yasui@mb.kyoto-phu.ac.jp
日本, Kyoto, 607-8414
Masayuki Yamashita
Department of Pharmaceutical Manufacturing Chemistry, Division of Medicinal Chemical Sciences,Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku
Email: yasui@mb.kyoto-phu.ac.jp
日本, Kyoto, 607-8414
Yutaka Yoshikawa
Department of Health, Sports, and Nutrition, Faculty of Health and Welfare,Kobe Women’s University, 4-7-2 Minatojima-nakamachi, Chuo-ku
Email: yasui@mb.kyoto-phu.ac.jp
日本, Kobe, 650-0046
Hiroyuki Yasui
Department of Analytical and Bioinorganic Chemistry, Division of Analytical and Physical Sciences,Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku
编辑信件的主要联系方式.
Email: yasui@mb.kyoto-phu.ac.jp
日本, Kyoto, 607-8414