Comparison of the Structural Features of Micron and Submicron Vaterite Particles and Their Efficiency for Intranasal Delivery of Anesthetic to the Brain


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Nanostructured spherical calcium carbonate particles with average sizes of 3.8 µm and 550 nm have been fabricated. Optimal conditions for adsorption of central anesthetic loperamide on these particles are found. The influence of particle size on the adsorption efficiency is studied. The efficiency of micron and submicron vaterite particles as carriers for intranasal loperamide delivery is compared using in vivo tests on laboratory animals.

作者简介

D. Trushina

National Research Centre “Kurchatov Institute,”; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences

编辑信件的主要联系方式.
Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 123182; Moscow, 119146; Moscow, 119333

T. Borodina

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation

Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 119333; Moscow, 119146

S. Sulyanov

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”

Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 119333; Moscow, 123182

J. Moiseeva

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 117485

N. Gulyaeva

Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences

Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 117485

T. Bukreeva

National Research Centre “Kurchatov Institute,”; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”
Russian Academy of Sciences

Email: trushina.d@mail.ru
俄罗斯联邦, Moscow, 123182; Moscow, 119333

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