Email this article Comparison of the Structural Features of Micron and Submicron Vaterite Particles and Their Efficiency for Intranasal Delivery of Anesthetic to the Brain
- Authors: Trushina D.B.1,2,3, Borodina T.N.3,2, Sulyanov S.N.3,1, Moiseeva J.V.4, Gulyaeva N.V.4, Bukreeva T.V.1,3
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Affiliations:
- National Research Centre “Kurchatov Institute,”
- Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
- Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences
- Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
- Issue: Vol 63, No 6 (2018)
- Pages: 998-1004
- Section: Nanomaterials and Ceramics
- URL: https://journals.rcsi.science/1063-7745/article/view/193243
- DOI: https://doi.org/10.1134/S1063774518060305
- ID: 193243
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Abstract
Nanostructured spherical calcium carbonate particles with average sizes of 3.8 µm and 550 nm have been fabricated. Optimal conditions for adsorption of central anesthetic loperamide on these particles are found. The influence of particle size on the adsorption efficiency is studied. The efficiency of micron and submicron vaterite particles as carriers for intranasal loperamide delivery is compared using in vivo tests on laboratory animals.
About the authors
D. B. Trushina
National Research Centre “Kurchatov Institute,”; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Author for correspondence.
Email: trushina.d@mail.ru
Russian Federation, Moscow, 123182; Moscow, 119146; Moscow, 119333
T. N. Borodina
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation
Email: trushina.d@mail.ru
Russian Federation, Moscow, 119333; Moscow, 119146
S. N. Sulyanov
Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences; National Research Centre “Kurchatov Institute,”
Email: trushina.d@mail.ru
Russian Federation, Moscow, 119333; Moscow, 123182
J. V. Moiseeva
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Email: trushina.d@mail.ru
Russian Federation, Moscow, 117485
N. V. Gulyaeva
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences
Email: trushina.d@mail.ru
Russian Federation, Moscow, 117485
T. V. Bukreeva
National Research Centre “Kurchatov Institute,”; Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,”Russian Academy of Sciences
Email: trushina.d@mail.ru
Russian Federation, Moscow, 123182; Moscow, 119333
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