Synthesis, Crystal Structure, Electrochemical Properties, and Biological Activity of 2-((1H-Benzimidazol-2-yl)methylamino)acetic Acid
- Authors: Sabithakala T.1, Bhargavi G.2, Venkata Ramana Reddy C.1
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Affiliations:
- Department of Chemistry
- School of Chemistry
- Issue: Vol 63, No 4 (2018)
- Pages: 600-605
- Section: Structure of Macromolecular Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/192704
- DOI: https://doi.org/10.1134/S1063774518040235
- ID: 192704
Cite item
Abstract
A water soluble compound, (2-((1H-benzimidazol-2-yl)methylamino)acetic acid, BIGH, has been synthesized and structurally characterized by elemental analysis, IR and UV spectroscopies, 1H-NMR, thermogravimetric and differential thermal analyses, and single crystal and powder X-ray diffraction. BIGH can act as a flexible planar ligand with three potential coordination sites. It crystallizes in a monoclinic system with the sp. gr. P21/c with the unit cell parameters, a = 9.3764(7) Å, b = 11.5031(8) Å, c = 10.0543(6) Å, and Z = 4. The crystal structure was stabilized through inter-molecular hydrogen bonds. The anti-microbial activity of the compound has been studied against Escherichia coli, Bacillus subtilis, Pseudomonas aeruginosa, and Staphylococcus aureus, which showed a good activity against Bacillus subtilis. Cyclic voltammogram of the compound shows that it is a redox-active molecule.
About the authors
T. Sabithakala
Department of Chemistry
Email: vrr9@jntuh.ac.in
India, Hyderabad, 500085
G. Bhargavi
School of Chemistry
Email: vrr9@jntuh.ac.in
India, Hyderabad, 500046
Ch. Venkata Ramana Reddy
Department of Chemistry
Author for correspondence.
Email: vrr9@jntuh.ac.in
India, Hyderabad, 500085