Crystal structure and packing analysis of nitrofurantoin N,N-dimethylformamide solvate
- Authors: Cvetkovski A.1, Ferretti V.2
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Affiliations:
- Faculty of Medical Sciences, Krste Misirkov bb
- Department of Chemical and Pharmaceutical Sciences
- Issue: Vol 61, No 4 (2016)
- Pages: 611-615
- Section: Structure of Organic Compounds
- URL: https://journals.rcsi.science/1063-7745/article/view/190164
- DOI: https://doi.org/10.1134/S1063774516040040
- ID: 190164
Cite item
Abstract
The N, N′-dimethylformamide solvated crystal of the drug nitrofurantoin has been prepared and analysed by single-crystal X-ray diffraction. The two co-crystallized molecules, in the 1 : 1 stoichiometric ratio, are linked by a medium/strong N–H···O hydrogen bond (N···O is 2.759 (3) Å) and a weaker C–H···O interaction to form isolated supramolecular adducts, that in turn are packed into the lattice framework mainly through C–H···O hydrogen bonds. Two-dimensional fingerprint plots of Hirshfeld surfaces are used to visualize, analyze and compare intermolecular interactions found in the title compound and in similar structures.
About the authors
A. Cvetkovski
Faculty of Medical Sciences, Krste Misirkov bb
Author for correspondence.
Email: aleksandar.cvetkovski@ugd.edu.mk
Macedonia, the former Yugoslav Republic of, Štip
V. Ferretti
Department of Chemical and Pharmaceutical Sciences
Email: aleksandar.cvetkovski@ugd.edu.mk
Italy, via Fossato di Mortara 17-27, Ferrara, I-44121