Production of Stable Cell Lines on the Basis of the Cultured RPMI 8866 B-Cells with Constant and Inducible Expression of the Human Immunodeficiency Virus Tat Protein
- 作者: Gorbacheva M.A.1, Tikhomirova M.A.2, Potashnikova D.M.3,4, Akbay B.5, Sheval E.V.2,3, Musinova Y.R.1,2
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隶属关系:
- Koltsov Institute of Developmental Biology, Russian Academy of Sciences
- Belozersky Institute of Physicochemical Biology, Moscow State University
- Biological Faculty, Moscow State University
- Atherothrombosis Laboratory, Evdokimov Moscow State University of Medicine and Dentistry
- UMR 8126, Université Paris-Sud Paris-Saclay, CNRS, Institut Gustave Roussy
- 期: 卷 50, 编号 5 (2019)
- 页面: 275-280
- 栏目: Mechanisms of Cell Proliferation and Differentiation
- URL: https://journals.rcsi.science/1062-3604/article/view/183955
- DOI: https://doi.org/10.1134/S1062360419050060
- ID: 183955
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详细
Highly-efficient antiretroviral therapy allows controlling human immunodeficiency virus (HIV) and preventing the development of immunodeficiency. However, the patients who receive therapy may develop different complications, including B-cell lymphomas. One of oncogenesis’ mechanisms in HIV-infected patients is associated with the activity of the viral Tat protein, which is able to penetrate into B-cells. In order to study the effect of the Tat protein on B-cells, a report is given on the production and characterization of the cell lines based on the cultured RPMI 8866 B-cell line demonstrating constant and inducible expression of the Tat protein.
作者简介
M. Gorbacheva
Koltsov Institute of Developmental Biology, Russian Academy of Sciences
Email: musinova@genebee.msu.ru
俄罗斯联邦, Moscow, 119334
M. Tikhomirova
Belozersky Institute of Physicochemical Biology, Moscow State University
Email: musinova@genebee.msu.ru
俄罗斯联邦, Moscow, 119992
D. Potashnikova
Biological Faculty, Moscow State University; Atherothrombosis Laboratory, Evdokimov Moscow State University of Medicine and Dentistry
Email: musinova@genebee.msu.ru
俄罗斯联邦, Moscow, 119992; Moscow, 109240
B. Akbay
UMR 8126, Université Paris-Sud Paris-Saclay, CNRS, Institut Gustave Roussy
Email: musinova@genebee.msu.ru
法国, Villejuif
E. Sheval
Belozersky Institute of Physicochemical Biology, Moscow State University; Biological Faculty, Moscow State University
Email: musinova@genebee.msu.ru
俄罗斯联邦, Moscow, 119992; Moscow, 119992
Y. Musinova
Koltsov Institute of Developmental Biology, Russian Academy of Sciences; Belozersky Institute of Physicochemical Biology, Moscow State University
编辑信件的主要联系方式.
Email: musinova@genebee.msu.ru
俄罗斯联邦, Moscow, 119334; Moscow, 119992
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