Developmental aspects of senescence

E. Yu. Brusentsev; M. A. Tikhonova; Yu. E. Herbeck; D. S. Ragaeva; I. N. Rozhkova; S. Ya. Amstislavsky

doi:10.1134/S1062360417020035

Developmental aspects of senescence

Authors: Brusentsev E.Y.¹, Tikhonova M.A.¹^,2^,3, Herbeck Y.E.¹, Ragaeva D.S.¹, Rozhkova I.N.¹, Amstislavsky S.Y.¹
Affiliations:
1. Institute of Cytology and Genetics, Siberian Branch
2. Institute of Physiology and Basic Medicine
3. Novosibirsk State University
Issue: Vol 48, No 2 (2017)
Pages: 93-105
Section: Reviews
URL: https://journals.rcsi.science/1062-3604/article/view/183544
DOI: https://doi.org/10.1134/S1062360417020035
ID: 183544

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Abstract

Different types of senescence and major theories of aging are reviewed, and mechanisms of this complex biological phenomenon are discussed. Emphasis is placed on changes in the nervous systems of mammals and humans with age. Experimental animal models for studying aging and modern approaches to the correction of age-related deterioration are considered. Chemicals and other factors that may alleviate agerelated disorders and slow down senescence are critically reviewed.