The role of testosterone in the regulation of P-glycoprotein functioning
- 作者: Shchulkin A.1, Yakusheva E.1, Chernykh I.1, Nikiforov A.1
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隶属关系:
- Pavlov Ryazan State Medical University
- 期: 卷 44, 编号 5 (2017)
- 页面: 524-530
- 栏目: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/182469
- DOI: https://doi.org/10.1134/S1062359017050168
- ID: 182469
如何引用文章
详细
The functional activity of P-glycoprotein (Pgp) was studied in Chinchilla rabbits after orchiectomy and administration of testosterone undecanoate after surgery. The functional activity of Pgp was determined by the pharmacokinetics of fexofenadine, its marker substrate. In addition, the localization of the transport protein was assessed in the liver, kidney, and jejunum by the immunohistochemistry. It was found that a decrease in the serum testosterone concentration after orchiectomy leads to an increase in Pgp activity on the 14th and 21st days after the surgery, which is accompanied by an increase in the staining intensity of Pgp-positive epithelium membranes of the proximal and distal renal tubules. It was found that the administration of testosterone at a dose of 6 mg/kg body weight in the period after the surgery neutralizes these changes.
作者简介
A. Shchulkin
Pavlov Ryazan State Medical University
编辑信件的主要联系方式.
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan, 390026
E. Yakusheva
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan, 390026
I. Chernykh
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan, 390026
A. Nikiforov
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
俄罗斯联邦, Ryazan, 390026