The role of testosterone in the regulation of P-glycoprotein functioning
- Авторлар: Shchulkin A.1, Yakusheva E.1, Chernykh I.1, Nikiforov A.1
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Мекемелер:
- Pavlov Ryazan State Medical University
- Шығарылым: Том 44, № 5 (2017)
- Беттер: 524-530
- Бөлім: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/182469
- DOI: https://doi.org/10.1134/S1062359017050168
- ID: 182469
Дәйексөз келтіру
Аннотация
The functional activity of P-glycoprotein (Pgp) was studied in Chinchilla rabbits after orchiectomy and administration of testosterone undecanoate after surgery. The functional activity of Pgp was determined by the pharmacokinetics of fexofenadine, its marker substrate. In addition, the localization of the transport protein was assessed in the liver, kidney, and jejunum by the immunohistochemistry. It was found that a decrease in the serum testosterone concentration after orchiectomy leads to an increase in Pgp activity on the 14th and 21st days after the surgery, which is accompanied by an increase in the staining intensity of Pgp-positive epithelium membranes of the proximal and distal renal tubules. It was found that the administration of testosterone at a dose of 6 mg/kg body weight in the period after the surgery neutralizes these changes.
Авторлар туралы
A. Shchulkin
Pavlov Ryazan State Medical University
Хат алмасуға жауапты Автор.
Email: alekseyshulkin@rambler.ru
Ресей, Ryazan, 390026
E. Yakusheva
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
Ресей, Ryazan, 390026
I. Chernykh
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
Ресей, Ryazan, 390026
A. Nikiforov
Pavlov Ryazan State Medical University
Email: alekseyshulkin@rambler.ru
Ресей, Ryazan, 390026