The Effect of Confounding Factors in Biomodeling of Intoxication
- Autores: Sosedova L.1, Yakimova N.1, Vokina V.1
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Afiliações:
- East Siberian Institute of Medical and Ecological Research
- Edição: Volume 46, Nº 6 (2019)
- Páginas: 608-614
- Seção: Animal and Human Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/183119
- DOI: https://doi.org/10.1134/S1062359019040149
- ID: 183119
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Resumo
The results of modeling intoxication in rats using lead acetate against the background of metabolic changes in the body and prenatal stress are presented. The motor activity and cognitive abilities, serum total cholesterol and lipid fractions, and bioelectric activity of the brain have been identified by testing the animals. It was found that intoxication with lead acetate against hyperglycemia or hyperlipidemia compared with the individual effects of lead acetate resulted in impaired cognitive abilities of animals and pronounced atherogenic changes, which included an increase in the concentrations of low-density lipoprotein cholesterol, triglycerides, and an atherogenic coefficient. It was recorded that lead intoxication complicated by metabolic disorders caused more prominent pathological changes in ECG parameters, such as tachycardia and a change in the duration of intraventricular conduction.
Sobre autores
L. Sosedova
East Siberian Institute of Medical and Ecological Research
Autor responsável pela correspondência
Email: sosedlar@mail.ru
Rússia, Angarsk, 665827
N. Yakimova
East Siberian Institute of Medical and Ecological Research
Email: sosedlar@mail.ru
Rússia, Angarsk, 665827
V. Vokina
East Siberian Institute of Medical and Ecological Research
Email: sosedlar@mail.ru
Rússia, Angarsk, 665827