The role of the tuftsin and Selank peptides in the regulation of primary and plasma homeostasis
- Authors: Lyapina L.A.1, Grigor’eva M.E.1, Obergan T.Y.1, Maistrenko E.S.1
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Affiliations:
- Faculty of Biology
- Issue: Vol 44, No 2 (2017)
- Pages: 228-230
- Section: Short Communications
- URL: https://journals.rcsi.science/1062-3590/article/view/182389
- DOI: https://doi.org/10.1134/S1062359017020121
- ID: 182389
Cite item
Abstract
Experimental data on the effect of the natural immunopeptide tuftsin and its synthetic counterpart on hemostasis parameters in vitro and in vivo when administered intranasally to animals (white laboratory rats) are given. It has been shown that in vitro both preparations induced a fibrin-depolymerization effect on fibrin that is not stabilized by factor XIIIa. For each preparation, it was noted that, when administered to rats, simultaneous antiplatelet, anticoagulant, and fibrin-depolymerization effects were observed in the blood plasma, with Selank having a more pronounced effect.
About the authors
L. A. Lyapina
Faculty of Biology
Author for correspondence.
Email: lyapinal@mail.ru
Russian Federation, Moscow, 119234
M. E. Grigor’eva
Faculty of Biology
Email: lyapinal@mail.ru
Russian Federation, Moscow, 119234
T. Yu. Obergan
Faculty of Biology
Email: lyapinal@mail.ru
Russian Federation, Moscow, 119234
E. S. Maistrenko
Faculty of Biology
Email: lyapinal@mail.ru
Russian Federation, Moscow, 119234