Genetic Variations in Nrf2-Keap1 Complex: A Step towards Understanding Cancer Resistance in Blind Mole Rats Cytotypes
- Authors: Dilara Fatma Akın-Balı 1, Teoman Kankılıç 2
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Affiliations:
- Faculty of Medicine, Medical Biology, Niğde Ömer Halisdemir University
- Faculty of Science Literature, Department of Biotechnology, Niğde Ömer Halisdemir University
- Issue: Vol 46, No 6 (2019)
- Pages: 547-554
- Section: Genetics
- URL: https://journals.rcsi.science/1062-3590/article/view/183109
- DOI: https://doi.org/10.1134/S1062359019060050
- ID: 183109
Cite item
Abstract
Abstract—The Nrf2-Keap1 regulation system plays a crucial role in cytoprotection against electrophilic/oxidative stress. Previous studies have identified missense mutations in Nrf2/Keap1 complex which abolish its activity. The amino acid corresponding to codon 212 in Keapl’s IVR domain is conserved as tyrosine (Y) among different mammalian species whereas only Nannospalax and two other species carry a cysteine (C) residue at this position. These species include Sperm whale and European hedgehog that live in hypoxic environment. In this study, we examined genetic variations in Nrf2-Keap1 complex, which was reported to be important in cancer pathogenesis in previous studies, in cancer resistant blind mole rat species with varying chromosome numbers (2n: 46–60) that we collected from different regions in Turkey. This study was the first to provide information on genetic variants in Nrf2/Keap1 complex of blind mole rats living in Turkey.
About the authors
Dilara Fatma Akın-Balı
Faculty of Medicine, Medical Biology, Niğde Ömer Halisdemir University
Author for correspondence.
Email: dilarafatmaakin@gmail.com
Turkey, Niğde
Teoman Kankılıç
Faculty of Science Literature, Department of Biotechnology, Niğde Ömer Halisdemir University
Email: dilarafatmaakin@gmail.com
Turkey, Niğde