The Study of Cognitive-Stimulating Activity of Fluorinated Tetrahydrocarbazole Derivatives and Behavioral Responses in Transgenic Tg6799 Mice with Alzheimer’s Disease
- Authors: Nikolaeva N.S.1, Maltsev A.V.1, Ovchinnikov R.K.1, Sokolov V.B.1, Aksinenko A.Y.1, Bovina E.V.1, Kinzirsky A.S.1
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 46, No 3 (2019)
- Pages: 268-276
- Section: Human and Animal Physiology
- URL: https://journals.rcsi.science/1062-3590/article/view/183049
- DOI: https://doi.org/10.1134/S1062359019030075
- ID: 183049
Cite item
Abstract
The cognitive-stimulating, neuroprotective effects of promising fluorinated tetrahydrocarbazole derivatives (CA-7043x and CA-7050x) on the hippocampus-dependent memory of outbred mice (CD1) and transgenic Tg6799 mice, as well as their effect on anxiety, locomotor activity, and orienting-exploratory behavior of animals, were studied. It was found that both compounds have a pronounced cognitive-stimulating effect on CD1 mice, but do not show neuroprotective effects on memory support in Tg6799 mice. It is noted that, in the open-field test, the CA-7050x compound has a positive effect on the orientating behavior, and the CA-7043x compound has a positive effect on the exploratory response in the nontransgenic control.
About the authors
N. S. Nikolaeva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Author for correspondence.
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. V. Maltsev
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
R. K. Ovchinnikov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
V. B. Sokolov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
E. V. Bovina
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432
A. S. Kinzirsky
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, Chernogolovka, Moscow oblast, 142432