Activation of α7-nicotinic acetylcholine receptors causes secretion of matrix metalloproteinases-9 in the human endometrium
- Authors: Krasnyi A.M.1,2, Volgina N.E.1, Sadekova A.A.1, Shchipitsyna V.S.1, Sukhikh G.T.1, Adamyan L.V.1, Ozernyuk N.D.2
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Affiliations:
- Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
- Koltzov Institute of Developmental Biology
- Issue: Vol 44, No 2 (2017)
- Pages: 109-112
- Section: Cell Biology
- URL: https://journals.rcsi.science/1062-3590/article/view/182361
- DOI: https://doi.org/10.1134/S1062359017020078
- ID: 182361
Cite item
Abstract
α7-Nicotinic acetylcholine receptors (α7nAChR) have been discovered and studied in the human endometrium for the first time. The expression of these receptors at the level of mRNA has been shown in the endometrial tissue by polymerase chain reaction and at the protein level by Western blot. It has been found that the addition of carbachol, an agonist of acetylcholine receptors, or PHA 543613, a selective activator of α7nAChR, to the primary culture of endometrial cells leads to regulated pulse secretion of matrix metalloproteinase- 9.
About the authors
A. M. Krasnyi
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology; Koltzov Institute of Developmental Biology
Author for correspondence.
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997; ul. Vavilova 26, Moscow, 119334
N. E. Volgina
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997
A. A. Sadekova
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997
V. S. Shchipitsyna
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997
G. T. Sukhikh
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997
L. V. Adamyan
Kulakov Research Center of Obstetrics, Gynecology, and Perinatology
Email: alexred@list.ru
Russian Federation, ul. Akademika Oparina 4, Moscow, 117997
N. D. Ozernyuk
Koltzov Institute of Developmental Biology
Email: alexred@list.ru
Russian Federation, ul. Vavilova 26, Moscow, 119334